Linked Life Data

20074773

Source:http://linkedlifedata.com/resource/pubmed/id/20074773

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-1-29
pubmed:abstractText
Phenanthrene, a major component of crude oil, is one of the most abundant PAHs in aquatic ecosystems, and is readily bioavailable and toxic to a range of marine invertebrates. Within bivalves, the haemolymph acts as a transfer medium for these pollutants and their metabolic products, leaving haemocytes susceptible to deleterious effects. Using a suite of biological endpoints, this study determined the sublethal (7-d exposure to 50, 100 and 200microgL(-1)) effects of phenanthrene on several oxidative stress and immunological parameters in the haemolymph of the commercially-important scallop Pecten maximus. Phenanthrene exposure (200microgL(-1)) resulted in immune modulation with significant reductions in cell membrane stability (P<0.05) and phagocytosis (P<0.05), and a significant increase in the number of total haemocytes (P<0.05). Oxidative stress was also observed with a significant decrease in total glutathione (P<0.05) and significantly increased levels of lipid peroxidation in the haemolymph (P<0.05). Changes in the cellular and biochemical endpoints observed in this study illustrate their potential use in assessing the subtle effects of contaminant exposure. Whilst previous reports have suggested a link between free radical generation and immune suppression in vertebrates, this is the first instance where oxidative stress and immune function have been measured together in the haemolymph of a bivalve mollusc, demonstrating a possible link between PAH-induced oxidative stress and the subsequent inhibition in haemocyte immune function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1879-1298
pubmed:author
pubmed:copyrightInfo
2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
779-84
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Effects of the model PAH phenanthrene on immune function and oxidative stress in the haemolymph of the temperate scallop Pecten maximus.
pubmed:affiliation
Ecotoxicology and Stress Biology Research Centre, University of Plymouth, Drake Circus, Devon, UK. marie.hannam@plymouth.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't