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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-3-19
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pubmed:abstractText |
Interleukin (IL)-7 is a factor essential for mouse and human thymopoiesis. Mouse thymocytes have altered sensitivities to IL-7 at different developmental stages. CD4/CD8 double positive (DP) mouse thymocytes are shielded from the influence of IL-7 because of loss of CD127 (IL-7Ralpha). In this study, we assessed IL-7 receptor expression and IL-7 signaling in human thymocytes. We found human DP cells to be severely limited in their ability to phosphorylate STAT-5 in response to IL-7. The relative expression levels of the IL-7-inducible proteins Bcl-2 and Mcl-1 were also lower in human DP cells, consistent with a stage-specific decrease in IL-7 responsiveness. IL-7 responses were restored in a subset of cells that matured past the DP stage. Unlike the regulation of IL-7 signaling in mouse thymocytes, loss of IL-7 signaling in human DP cells was not due to absence of CD127, but instead correlated with downregulation of CD132 (common gamma chain).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-10216100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-10379911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-10727454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-12010786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-12360214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-12705851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-12847229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-14668867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-15034036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-15035850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-15226449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-15365098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-15611228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-15928199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-16647713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-17032169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-17259970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-17268520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-17713021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-17768066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-18070935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-18321477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-18523275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-18562142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-18948571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-3500264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-7534200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-7688021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-9099797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-9215626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-9505193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20074604-9952357
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin Receptor Common gamma...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-7 receptor, alpha chain
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1879-1166
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pubmed:author |
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pubmed:copyrightInfo |
.
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pubmed:issnType |
Electronic
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
329-33
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pubmed:dateRevised |
2011-7-27
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pubmed:meshHeading |
pubmed-meshheading:20074604-Animals,
pubmed-meshheading:20074604-Antigens, CD4,
pubmed-meshheading:20074604-Antigens, CD8,
pubmed-meshheading:20074604-Cell Differentiation,
pubmed-meshheading:20074604-Cells, Cultured,
pubmed-meshheading:20074604-Child, Preschool,
pubmed-meshheading:20074604-Humans,
pubmed-meshheading:20074604-Infant,
pubmed-meshheading:20074604-Infant, Newborn,
pubmed-meshheading:20074604-Interleukin Receptor Common gamma Subunit,
pubmed-meshheading:20074604-Interleukin-7,
pubmed-meshheading:20074604-Mice,
pubmed-meshheading:20074604-Precursor Cells, T-Lymphoid,
pubmed-meshheading:20074604-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:20074604-Receptors, Interleukin-7,
pubmed-meshheading:20074604-STAT5 Transcription Factor,
pubmed-meshheading:20074604-Signal Transduction,
pubmed-meshheading:20074604-Thymus Gland
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pubmed:year |
2010
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pubmed:articleTitle |
Differential IL-7 responses in developing human thymocytes.
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pubmed:affiliation |
Department of Surgery, University of Oklahoma College of Medicine, Tulsa, OK, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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