Source:http://linkedlifedata.com/resource/pubmed/id/20074473
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-1-15
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| pubmed:abstractText |
Allergic rhinitis (AR) is characterized by Th2 polarized immune response, such as increased IL-4 and reduced IFN-gamma production. Sublingual allergen-specific immunotherapy (SLIT) induces several immunological changes, most of which are still little known. The aim of this study is firstly to investigate the changes of allergen-specific IgE, IgG, IgG4, and IgA serum levels after SLIT. Secondly, this study aims at relating immunoglobulin (Ig) values with some Th1-, Th2-, and Treg-dependent cytokines. Twenty-three patients with pollen-induced AR were enrolled, and they assumed two pre-seasonal SLIT courses for 2 years. Serum allergen-specific IgE, IgG, IgG4 and IgA levels were determined by ELISA method at baseline and after each SLIT course. Serum IL-4, IFN-gamma, IL-10, and TGF-beta levels were also assessed. Allergen-specific IgE, IgG, IgG4, and IgA serum levels significantly increased after SLIT. Serum TGF-beta significantly increased after SLIT. There was a significant correlation between IgA and TGF-beta, both after the first and the second SLIT course. In conclusion, the present study provides the first evidence that pollen SLIT significantly affects Ig production, mainly concerning IgA; and IgA increase is related with TGF-beta production. Moreover, this is the first study that measured Ig classes by using a quantitative method.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Plant,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0394-6320
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1089-96
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| pubmed:meshHeading |
pubmed-meshheading:20074473-Administration, Sublingual,
pubmed-meshheading:20074473-Adult,
pubmed-meshheading:20074473-Antibodies,
pubmed-meshheading:20074473-Antigens, Plant,
pubmed-meshheading:20074473-Biological Markers,
pubmed-meshheading:20074473-Cytokines,
pubmed-meshheading:20074473-Desensitization, Immunologic,
pubmed-meshheading:20074473-Drug Administration Schedule,
pubmed-meshheading:20074473-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20074473-Female,
pubmed-meshheading:20074473-Humans,
pubmed-meshheading:20074473-Male,
pubmed-meshheading:20074473-Middle Aged,
pubmed-meshheading:20074473-Pilot Projects,
pubmed-meshheading:20074473-Pollen,
pubmed-meshheading:20074473-Rhinitis, Allergic, Seasonal,
pubmed-meshheading:20074473-Time Factors,
pubmed-meshheading:20074473-Transforming Growth Factor beta,
pubmed-meshheading:20074473-Treatment Outcome,
pubmed-meshheading:20074473-Up-Regulation,
pubmed-meshheading:20074473-Young Adult
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| pubmed:articleTitle |
Sublingual immunotherapy affects specific antibody and TGF-beta serum levels in patients with allergic rhinitis.
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| pubmed:affiliation |
Semeiotica e Metodologia Medica I, DIMI, University of Genoa, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy. gio.cip@libero.it
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| pubmed:publicationType |
Journal Article,
Clinical Trial
|