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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0005516,
umls-concept:C0205210,
umls-concept:C0599894,
umls-concept:C0681890,
umls-concept:C0871261,
umls-concept:C1521840,
umls-concept:C1527249,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
6
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pubmed:dateCreated |
2010-1-14
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pubmed:abstractText |
Targeted mAbs to VEGFR and EGFR are well-established therapies for the treatment of colorectal cancer. The costs and toxicities associated with these novel treatments are not insignificant, and therefore molecular markers that predict treatment efficacy are needed to individualize the therapy administered to each patient. Recent data in this research field support KRAS mutation testing to guide the selection of EGFR inhibitors for the treatment of colorectal cancer. This review discusses the evidence that KRAS mutation analysis can indicate a beneficial response to EGFR inhibitors, and the potential and limitations of other mutations in the VEGF and EGF signaling pathways as predictive molecular markers in this setting.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/BRAF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/KRAS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PTEN Phosphohydrolase,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins B-raf,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vascular Endothelial...,
http://linkedlifedata.com/resource/pubmed/chemical/TP53 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/bevacizumab,
http://linkedlifedata.com/resource/pubmed/chemical/raf Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
2040-3445
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
611-22
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20072938-Angiogenesis Inhibitors,
pubmed-meshheading:20072938-Antibodies,
pubmed-meshheading:20072938-Antibodies, Monoclonal,
pubmed-meshheading:20072938-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:20072938-Biological Markers,
pubmed-meshheading:20072938-Clinical Trials as Topic,
pubmed-meshheading:20072938-Colorectal Neoplasms,
pubmed-meshheading:20072938-DNA Mutational Analysis,
pubmed-meshheading:20072938-Humans,
pubmed-meshheading:20072938-MAP Kinase Signaling System,
pubmed-meshheading:20072938-PTEN Phosphohydrolase,
pubmed-meshheading:20072938-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:20072938-Polymorphism, Genetic,
pubmed-meshheading:20072938-Proto-Oncogene Proteins,
pubmed-meshheading:20072938-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:20072938-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20072938-Receptor, Epidermal Growth Factor,
pubmed-meshheading:20072938-Receptors, Vascular Endothelial Growth Factor,
pubmed-meshheading:20072938-Signal Transduction,
pubmed-meshheading:20072938-Treatment Outcome,
pubmed-meshheading:20072938-Tumor Suppressor Protein p53,
pubmed-meshheading:20072938-raf Kinases,
pubmed-meshheading:20072938-ras Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Predictive biomarkers of clinical response to targeted antibodies in colorectal cancer.
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pubmed:affiliation |
Concord Repatriation General Hospital, Department of Medical Oncology, Sydney Cancer Centre, Hospital Road, New South Wales 2139, Australia.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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