Source:http://linkedlifedata.com/resource/pubmed/id/20071593
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-1-14
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| pubmed:abstractText |
Alanine aminotransferase (ALT) is a routine parameter in the assessment and monitoring of chronic hepatitis C viral (HCV) infection. Hepatitis C virus-infected African Americans (AAs) have been reported to have lower ALT levels. In this retrospective, cross-sectional, multicenter study, host and virological factors possibly associated with ALT levels were analyzed by multivariate regression analyses among HIV/HCV-coinfected patients. Of the 289 patients included, 142 were African Americans and 144 Caucasians. In multivariate analysis, only HCV genotype 3 (B 0.2 [95% CI 13.39-52.33]; P = .001) and HCV RNA >500 000 IU/mL (B 3.1 [95% CI 7.67-34.75]; P = .002) were independent predictors of higher ALT levels. Per the American Association for the Study of Liver Disease (AASLD) definition, 18.2% had ALT levels within normal limits. Male sex and HCV RNA <500 000 IU/mL predicted ALT within normal limits. Hepatitis C viral factors rather than race were associated with ALT levels in this HIV/HCV-coinfected population. ALT were within normal limits in 18% of patients, who more often were male and had lower Hepatitis C viral load.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1545-1097
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
15-9
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| pubmed:meshHeading |
pubmed-meshheading:20071593-Adult,
pubmed-meshheading:20071593-African Americans,
pubmed-meshheading:20071593-Alanine Transaminase,
pubmed-meshheading:20071593-Comorbidity,
pubmed-meshheading:20071593-Cross-Sectional Studies,
pubmed-meshheading:20071593-European Continental Ancestry Group,
pubmed-meshheading:20071593-Female,
pubmed-meshheading:20071593-Genotype,
pubmed-meshheading:20071593-HIV,
pubmed-meshheading:20071593-HIV Infections,
pubmed-meshheading:20071593-Hepacivirus,
pubmed-meshheading:20071593-Hepatitis C,
pubmed-meshheading:20071593-Humans,
pubmed-meshheading:20071593-Italy,
pubmed-meshheading:20071593-Male,
pubmed-meshheading:20071593-Multivariate Analysis,
pubmed-meshheading:20071593-North Carolina,
pubmed-meshheading:20071593-Retrospective Studies,
pubmed-meshheading:20071593-Viral Load
|
| pubmed:articleTitle |
Virological rather than host factors are associated with transaminase levels among HIV/HCV-coinfected patients.
|
| pubmed:affiliation |
Division on Gastroenterology, Department of Internal Medicine, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
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| pubmed:publicationType |
Journal Article,
Multicenter Study
|