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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0021201,
umls-concept:C0023273,
umls-concept:C0185117,
umls-concept:C0205210,
umls-concept:C0332325,
umls-concept:C0370215,
umls-concept:C0449438,
umls-concept:C1979963,
umls-concept:C2003903,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
2010-2-10
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|
pubmed:abstractText |
Clinical resistance to pentavalent antimonials results from an interplay between uptake, efflux and sequestration in Leishmania. Aquaglyceroporins (AQPs) have been shown to facilitate uptake of trivalent metalloids. Down-regulation of AQP1 in Leishmania results in resistance to trivalent antimony, whereas overexpression of AQP1 in drug-resistant parasites can reverse the resistance. The present work investigates the role of AQP1 in monitoring antimonial resistance in Indian leishmaniasis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1460-2091
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
496-507
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pubmed:meshHeading |
pubmed-meshheading:20067981-Amino Acid Sequence,
pubmed-meshheading:20067981-Antimony,
pubmed-meshheading:20067981-Antiprotozoal Agents,
pubmed-meshheading:20067981-Aquaporin 1,
pubmed-meshheading:20067981-DNA, Protozoan,
pubmed-meshheading:20067981-Drug Resistance,
pubmed-meshheading:20067981-Gene Expression Profiling,
pubmed-meshheading:20067981-Genes, Protozoan,
pubmed-meshheading:20067981-Humans,
pubmed-meshheading:20067981-India,
pubmed-meshheading:20067981-Leishmania donovani,
pubmed-meshheading:20067981-Leishmaniasis, Cutaneous,
pubmed-meshheading:20067981-Leishmaniasis, Visceral,
pubmed-meshheading:20067981-Models, Biological,
pubmed-meshheading:20067981-Models, Molecular,
pubmed-meshheading:20067981-Molecular Sequence Data,
pubmed-meshheading:20067981-Parasitic Sensitivity Tests,
pubmed-meshheading:20067981-Polymerase Chain Reaction,
pubmed-meshheading:20067981-Polymorphism, Genetic,
pubmed-meshheading:20067981-Protozoan Proteins,
pubmed-meshheading:20067981-Sequence Alignment,
pubmed-meshheading:20067981-Sequence Analysis, DNA,
pubmed-meshheading:20067981-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Assessing aquaglyceroporin gene status and expression profile in antimony-susceptible and -resistant clinical isolates of Leishmania donovani from India.
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pubmed:affiliation |
School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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