|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2010-2-12
|
|
pubmed:abstractText |
Neurofibrillary tangles (NFT), a cardinal neuropathological feature of Alzheimer's disease (AD) that is highly correlated with synaptic loss and dementia severity, appear to be partly attributable to increased phosphorylation of the microtubule stabilizing protein tau at certain AD-related residues. Identifying the kinases involved in the pathologic phosphorylation of tau may provide targets at which to aim new AD-modifying treatments.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-10464279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-11311121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-11408621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-11837744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-12214129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-12446970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-12464279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-12471243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-12499843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-13678666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-14032480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-14975685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-15567511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-15789031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-16257959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-1644173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-16504338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-17135279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-17168644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-17416103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-17906291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-17928404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-17932415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-2427509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-2560640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-3088567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-7706316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-7786411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-8590813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-8674537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-8687413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-8999860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20067632-9735171
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1471-2164
|
|
pubmed:author |
pubmed-author:AzorsaDavid ODO,
pubmed-author:BasuGargi DGD,
pubmed-author:BeaudryChristianC,
pubmed-author:BisanzKristen MKM,
pubmed-author:BrautigamGillian RGR,
pubmed-author:DickeyChadC,
pubmed-author:DunckleyTravisT,
pubmed-author:FrostDanielleD,
pubmed-author:GroverAndrewA,
pubmed-author:GwinnLeslieL,
pubmed-author:HernandezJoseph AJA,
pubmed-author:HolzDavid RDR,
pubmed-author:HuttonMichaelM,
pubmed-author:Meec hoovetBessieB,
pubmed-author:MoussesSpyroS,
pubmed-author:ReimanEric MEM,
pubmed-author:RobesonRiLee HRH,
pubmed-author:RogersJosephJ,
pubmed-author:StephanDietrich ADA
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
25
|
|
pubmed:dateRevised |
2010-9-27
|
|
pubmed:meshHeading |
pubmed-meshheading:20067632-Alzheimer Disease,
pubmed-meshheading:20067632-Cell Line, Tumor,
pubmed-meshheading:20067632-Gene Expression Profiling,
pubmed-meshheading:20067632-Genetic Testing,
pubmed-meshheading:20067632-Genome, Human,
pubmed-meshheading:20067632-Humans,
pubmed-meshheading:20067632-Phosphorylation,
pubmed-meshheading:20067632-Protein Kinases,
pubmed-meshheading:20067632-RNA, Small Interfering,
pubmed-meshheading:20067632-Up-Regulation,
pubmed-meshheading:20067632-tau Proteins
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.
|
|
pubmed:affiliation |
Pharmaceutical Genomics Division, Translational Genomics Research Institute, Scottsdale, Arizona 85251, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
