|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0010592,
umls-concept:C0018823,
umls-concept:C0035015,
umls-concept:C0205178,
umls-concept:C0332157,
umls-concept:C0450240,
umls-concept:C0599918,
umls-concept:C0680022,
umls-concept:C1548437,
umls-concept:C1706210,
umls-concept:C1711207,
umls-concept:C1882417,
umls-concept:C1882923,
umls-concept:C2347567
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2010-1-11
|
|
pubmed:abstractText |
We hypothesized that genetic variation of ATP-binding cassette subfamily B member 1 (ABCB1) that encodes P-glycoprotein (involved in the uptake of cyclosporin A [CsA]) contributes to trough drug concentrations and thereby to CsA's immunosuppressive and toxic effects.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1534-6080
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
89
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
75-82
|
|
pubmed:meshHeading |
pubmed-meshheading:20061922-ATP-Binding Cassette Transporters,
pubmed-meshheading:20061922-Acute Disease,
pubmed-meshheading:20061922-Adolescent,
pubmed-meshheading:20061922-Adult,
pubmed-meshheading:20061922-Aged,
pubmed-meshheading:20061922-Cyclosporine,
pubmed-meshheading:20061922-Female,
pubmed-meshheading:20061922-Genotype,
pubmed-meshheading:20061922-Graft Rejection,
pubmed-meshheading:20061922-Heart Transplantation,
pubmed-meshheading:20061922-Humans,
pubmed-meshheading:20061922-Immunosuppressive Agents,
pubmed-meshheading:20061922-Male,
pubmed-meshheading:20061922-Middle Aged,
pubmed-meshheading:20061922-P-Glycoproteins,
pubmed-meshheading:20061922-Polymerase Chain Reaction,
pubmed-meshheading:20061922-Polymorphism, Genetic,
pubmed-meshheading:20061922-Predictive Value of Tests,
pubmed-meshheading:20061922-Retrospective Studies,
pubmed-meshheading:20061922-Young Adult
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
ATP-binding cassette subfamily B member 1 polymorphisms do not determine cyclosporin exposure, acute rejection or nephrotoxicity after heart transplantation.
|
|
pubmed:affiliation |
Transplant Unit, Royal Brompton and Harefield NHS Trust, Harefield Hospital, Harefield, Middlesex, United Kingdom.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
