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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-4-25
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pubmed:abstractText |
Fibroblast growth factor stimulates proliferation and subsequent differentiation of precursor cells isolated from the neuroepithelium of embryonic day 10 mice in vitro. Here we show that fibroblast growth factor-induced proliferation is dependent on the presence of insulin-like growth factors (IGFs) and that IGF-I is endogenously produced by the neuroepithelial cells. Blocking of endogenous IGF-I activity with anti-IGF-I antibodies results in complete inhibition of fibroblast growth factor-mediated proliferation and in cell death. IGF-I alone acts as a survival agent. These observations correlate with the detection of transcripts for IGF-I and basic fibroblast growth factor in freshly isolated neuroepithelium and are consistent with an autocrine action of these factors in early brain development in vivo.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-1001251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-1689490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-1701728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-2112611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-2469478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-2570164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-2648568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-2668264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-2828872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-2918032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-2937782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-2998733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-3013624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-3032582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-3045135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-3129729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-3205305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-3293998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-3422422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-3459161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-3460078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-3514004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-3774549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-3907275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-6133596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-6297754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-6371813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2006157-7239014
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2199-203
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2006157-Animals,
pubmed-meshheading:2006157-Antibodies,
pubmed-meshheading:2006157-Autoradiography,
pubmed-meshheading:2006157-Cell Division,
pubmed-meshheading:2006157-Cells, Cultured,
pubmed-meshheading:2006157-DNA Replication,
pubmed-meshheading:2006157-Embryo, Mammalian,
pubmed-meshheading:2006157-Epithelial Cells,
pubmed-meshheading:2006157-Epithelium,
pubmed-meshheading:2006157-Fibroblast Growth Factor 2,
pubmed-meshheading:2006157-Insulin-Like Growth Factor I,
pubmed-meshheading:2006157-Kinetics,
pubmed-meshheading:2006157-Mesencephalon,
pubmed-meshheading:2006157-Mice,
pubmed-meshheading:2006157-Mice, Inbred CBA,
pubmed-meshheading:2006157-Recombinant Proteins,
pubmed-meshheading:2006157-Telencephalon,
pubmed-meshheading:2006157-Thymidine,
pubmed-meshheading:2006157-Tritium
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pubmed:year |
1991
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pubmed:articleTitle |
Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I.
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pubmed:affiliation |
Walter and Eliza Hall Institute of Medical Research, Royal Parade, Parkville, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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