Linked Life Data

20061346

Source:http://linkedlifedata.com/resource/pubmed/id/20061346

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
48
pubmed:dateCreated
2010-5-26
pubmed:abstractText
The rational design of interventions is critical to controlling communicable diseases, especially in urban environments. In the case of the Chagas disease vector Triatoma infestans, successful control is stymied by the return of the insect after the effectiveness of the insecticide wanes. Here, we adapt a genetic algorithm, originally developed for the travelling salesman problem, to improve the spatio-temporal design of insecticide campaigns against T. infestans, in a complex urban environment. We find a strategy that reduces the expected instances of vector return 34-fold compared with the current strategy of sequential insecticide application to spatially contiguous communities. The relative success of alternative control strategies depends upon the duration of the effectiveness of the insecticide, and it shows chaotic fluctuations in response to unforeseen delays in a control campaign. We use simplified models to analyse the outcomes of qualitatively different spatio-temporal strategies. Our results provide a detailed procedure to improve control efforts for an urban Chagas disease vector, as well as general guidelines for improving the design of interventions against other disease agents in complex environments.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-10677766, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-11791988, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-12219120, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-15642975, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-15757679, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-16619592, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-16836826, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-17044877, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-17073082, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-17360397, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-18160979, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-18773972, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-18840739, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-19156190, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-19324686, http://linkedlifedata.com/resource/pubmed/commentcorrection/20061346-8155515
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1742-5662
pubmed:author
pubmed:issnType
Electronic
pubmed:day
6
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1061-70
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Rational spatio-temporal strategies for controlling a Chagas disease vector in urban environments.
pubmed:affiliation
Department of Biology, University of Pennsylvania, 219 Carolyn Lynch Laboratories, Philadelphia, PA 19104, USA. mzlevy@gmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural