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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-4-12
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pubmed:abstractText |
Mycophenolate mofetil (MMF) is an effective and commonly used immunosuppressant but has frequent adverse events. Genetic polymorphisms may contribute to variability in MMF efficacy and related complications. In this study we explore the distribution frequencies of common single nucleotide polymorphisms (SNPs) of IMPDH1, IMPDH2 and ABCC2 and investigate whether these SNPs influence MMF adverse events in 59 pediatric heart recipients.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1557-3117
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
509-16
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pubmed:meshHeading |
pubmed-meshheading:20061166-Adolescent,
pubmed-meshheading:20061166-Alleles,
pubmed-meshheading:20061166-Bone Marrow Cells,
pubmed-meshheading:20061166-Child,
pubmed-meshheading:20061166-Child, Preschool,
pubmed-meshheading:20061166-Cohort Studies,
pubmed-meshheading:20061166-Dose-Response Relationship, Drug,
pubmed-meshheading:20061166-Drug Administration Schedule,
pubmed-meshheading:20061166-Drug Therapy, Combination,
pubmed-meshheading:20061166-Female,
pubmed-meshheading:20061166-Gastroenteritis,
pubmed-meshheading:20061166-Genetic Predisposition to Disease,
pubmed-meshheading:20061166-Genotype,
pubmed-meshheading:20061166-Heart Transplantation,
pubmed-meshheading:20061166-Humans,
pubmed-meshheading:20061166-IMP Dehydrogenase,
pubmed-meshheading:20061166-Immunosuppressive Agents,
pubmed-meshheading:20061166-Infant,
pubmed-meshheading:20061166-Male,
pubmed-meshheading:20061166-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:20061166-Mycophenolic Acid,
pubmed-meshheading:20061166-Polymorphism, Single Nucleotide
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pubmed:year |
2010
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pubmed:articleTitle |
Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients.
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pubmed:affiliation |
Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania 15201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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