Linked Life Data

20061067

Source:http://linkedlifedata.com/resource/pubmed/id/20061067

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-3-8
pubmed:abstractText
The purpose of the present work was to investigate, following previous works, naphthylchalcones as antihyperglycemic agent in glucose loaded animal model, insulin secretion as well as the action of these compounds on glucose uptake in a target tissue of insulin. The naphthylchalcones were found to have an acute serum glucose-lowering effect in hyperglycemic normal rats. In addition, chalcones 2 and 4 stimulated significantly the insulin secretion induced by glucose. These results suggest that the presence of nitro group and their position in the phenyl rings are responsible for the antihyperglycemic activity of chalcones. Additionally, the effect of chalcones on serum glucose-lowering seems to be a consequence of insulin secretion and these chalcones represent potential compounds with strong antihyperglycemic properties.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1768-3254
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1332-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Antihyperglycemic activity of naphthylchalcones.
pubmed:affiliation
Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina Campus Universitário, Bairro Trindade, Cx. Postal 5069, CEP: 88040-970, Florianópolis, Santa Catarina, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't