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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-17
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pubmed:abstractText |
The aim of this study was to evaluate, in terms of dog macrophage killing ability in vitro, a vaccine based on Leishmania infantum promastigote soluble antigen (LSA) formulated with three different adjuvants (BCG, AdjuPrime, MPL/TDM/CWS). A significant increase of the macrophage killing ability was observed in dogs vaccinated with LSA+MPL/TDM/CWS after 1 month from vaccination. A similar increase of macrophage parasitocidal ability was present only after 5 months in dogs vaccinated with LSA+BCG or LSA+AdjuPrime. In all dogs the augmented killing percentage was still present after 12 months from vaccination. Therefore, in particular LSA+MPL/TDM/CWS vaccine seems promising for further studies in dogs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6,6'-dicorynomycolyl trehalose,
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/BCG Vaccine,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Wall Skeleton,
http://linkedlifedata.com/resource/pubmed/chemical/Cord Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Leishmaniasis Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid A,
http://linkedlifedata.com/resource/pubmed/chemical/monophosphoryl lipid A
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1878-1667
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pubmed:author |
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pubmed:copyrightInfo |
2009 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-82
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pubmed:meshHeading |
pubmed-meshheading:20061026-Adjuvants, Immunologic,
pubmed-meshheading:20061026-Animals,
pubmed-meshheading:20061026-Antigens, Protozoan,
pubmed-meshheading:20061026-BCG Vaccine,
pubmed-meshheading:20061026-Cell Wall Skeleton,
pubmed-meshheading:20061026-Cord Factors,
pubmed-meshheading:20061026-Dog Diseases,
pubmed-meshheading:20061026-Dogs,
pubmed-meshheading:20061026-Female,
pubmed-meshheading:20061026-Humans,
pubmed-meshheading:20061026-Leishmania infantum,
pubmed-meshheading:20061026-Leishmaniasis,
pubmed-meshheading:20061026-Leishmaniasis Vaccines,
pubmed-meshheading:20061026-Leukocytes, Mononuclear,
pubmed-meshheading:20061026-Lipid A,
pubmed-meshheading:20061026-Macrophages,
pubmed-meshheading:20061026-Male,
pubmed-meshheading:20061026-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Comparison between three adjuvants for a vaccine against canine leishmaniasis: In vitro evaluation of macrophage killing ability.
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pubmed:affiliation |
Dipartimento di Scienze Biomediche, University of Foggia, Ospedali Riuniti, Italy. t.trotta@unifg.it
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Clinical Trial, Phase I
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