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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-5-31
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pubmed:abstractText |
For the first time three different natural compounds, isolated from hairy roots of Astragalus membranaceus, cultivated in airlift bioreactor were tested for their cytotoxic potential and apoptosis induction in a panel of human tumor cell lines. Root cultures, cultivated in bioreactor gave 18.5 g l(-1) dry wt roots with the highest astragaloside production in vitro up to now - 1.64% (astragaloside I), 1.12% (astragaloside II) and 1.08% (astragaloside III). In this manner the production in airlift bioreactor can be used as means of reliable supply of cycloartane saponins to extend the research to human clinical studies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1873-6971
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
447-51
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pubmed:meshHeading |
pubmed-meshheading:20060881-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:20060881-Astragalus membranaceus,
pubmed-meshheading:20060881-Bioreactors,
pubmed-meshheading:20060881-Cell Culture Techniques,
pubmed-meshheading:20060881-Cell Line, Tumor,
pubmed-meshheading:20060881-Humans,
pubmed-meshheading:20060881-Neoplasms,
pubmed-meshheading:20060881-Plant Extracts,
pubmed-meshheading:20060881-Plant Roots,
pubmed-meshheading:20060881-Saponins,
pubmed-meshheading:20060881-Triterpenes
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pubmed:year |
2010
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pubmed:articleTitle |
Effects of cycloartane saponins from hairy roots of Astragalus membranaceus Bge., on human tumor cell targets.
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pubmed:affiliation |
Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria. ionkova@pharmfac.acad.bg
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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