Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-2-17
pubmed:abstractText
The type III secretion system (T3SS) is essential for the infectivity of many pathogenic Gram-negative bacteria. The T3SS contains proteins that form a channel in the inner and outer bacterial membranes, as well as an extracellular needle that is used for transporting and injecting effector proteins into a host cell. The homology between the T3SS and the bacterial flagellar system has been firmly established, based upon both sequence similarities between respective proteins in the two systems and the structural homology of higher-order assemblies. It has previously been shown that the Shigella flexneri needle has a helical symmetry of approximately 5.6 subunits/turn, which is quite similar to that of the most intensively studied flagellar filament (from Salmonella typhimurium), which has approximately 5.5 subunits/turn. We now show that the Sa. typhimurium needle, expected by homology arguments to be more similar to the Sa. typhimurium flagellar filament than is the needle from Shigella, actually has approximately 6.3 subunits/turn. It is not currently understood how host cell contact, made at the tip of the needle, is communicated to the secretory system at the base. In contrast to the Sa. typhimurium flagellar filament, which shows a nearly crystalline order, the Sa. typhimurium needle has a highly variable symmetry, which could be used to transmit information about host cell contact.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-10944190, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-11125866, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-11687484, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-12571230, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-12631703, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-12904785, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-15528446, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-16227202, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-16243352, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-16501225, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-16533600, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-16888041, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-16919474, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-17617421, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-18234857, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-18420936, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-3521658, http://linkedlifedata.com/resource/pubmed/commentcorrection/20060835-9461078
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1089-8638
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
12
pubmed:volume
396
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1392-7
pubmed:dateRevised
2011-7-26
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The structure of the Salmonella typhimurium type III secretion system needle shows divergence from the flagellar system.
pubmed:affiliation
Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, Charlottesville, VA 22908-0733, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural