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pubmed-article:20060833pubmed:abstractTextThe recent recognition of the importance of transforming growth factor beta (TGF-beta) in mediating many cellular immune functions has popularized the use of mouse models where TGF-beta signaling is blocked in specific cell types. However, there are some caveats affiliated with each model. Here we describe and show evidence for some of the limitations of these models and provide insight into ways to improve the utility of these animals for in vivo studies.lld:pubmed
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pubmed-article:20060833pubmed:authorpubmed-author:FlavellRichar...lld:pubmed
pubmed-article:20060833pubmed:authorpubmed-author:SanjabiShomys...lld:pubmed
pubmed-article:20060833pubmed:copyrightInfo2010 Elsevier B.V. All rights reserved.lld:pubmed
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pubmed-article:20060833pubmed:articleTitleOvercoming the hurdles in using mouse genetic models that block TGF-beta signaling.lld:pubmed
pubmed-article:20060833pubmed:affiliationYale University School of Medicine, New Haven, CT 06520, USA.lld:pubmed
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