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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2010-2-17
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pubmed:abstractText |
The recent recognition of the importance of transforming growth factor beta (TGF-beta) in mediating many cellular immune functions has popularized the use of mouse models where TGF-beta signaling is blocked in specific cell types. However, there are some caveats affiliated with each model. Here we describe and show evidence for some of the limitations of these models and provide insight into ways to improve the utility of these animals for in vivo studies.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-10714683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-10748236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-1436033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-15374963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-15852008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-16551245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-16788095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-16973386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-16973387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-18400189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-18516051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-18669656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-18692464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-18931678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-18997793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-19604492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20060833-19604493
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11c,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/OVA-8,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/transforming growth factor-beta...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1872-7905
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pubmed:author |
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pubmed:copyrightInfo |
2010 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
353
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-4
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pubmed:dateRevised |
2011-7-25
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pubmed:meshHeading |
pubmed-meshheading:20060833-Adoptive Transfer,
pubmed-meshheading:20060833-Animals,
pubmed-meshheading:20060833-Antigens, CD11c,
pubmed-meshheading:20060833-Antigens, CD4,
pubmed-meshheading:20060833-Cell Survival,
pubmed-meshheading:20060833-Epitopes,
pubmed-meshheading:20060833-Genes, RAG-1,
pubmed-meshheading:20060833-Genes, T-Cell Receptor,
pubmed-meshheading:20060833-Genotype,
pubmed-meshheading:20060833-Immunity, Cellular,
pubmed-meshheading:20060833-Listeria monocytogenes,
pubmed-meshheading:20060833-Mice,
pubmed-meshheading:20060833-Mice, Inbred C57BL,
pubmed-meshheading:20060833-Mice, Transgenic,
pubmed-meshheading:20060833-Models, Animal,
pubmed-meshheading:20060833-Ovalbumin,
pubmed-meshheading:20060833-Peptide Fragments,
pubmed-meshheading:20060833-Phenotype,
pubmed-meshheading:20060833-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20060833-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:20060833-Signal Transduction,
pubmed-meshheading:20060833-T-Lymphocytes,
pubmed-meshheading:20060833-Time Factors,
pubmed-meshheading:20060833-Transforming Growth Factor beta
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pubmed:year |
2010
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pubmed:articleTitle |
Overcoming the hurdles in using mouse genetic models that block TGF-beta signaling.
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pubmed:affiliation |
Yale University School of Medicine, New Haven, CT 06520, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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