Linked Life Data

20060823

Source:http://linkedlifedata.com/resource/pubmed/id/20060823

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-3-1
pubmed:abstractText
Less is known about the connection between the malfunction of betaarrestins and developmental defects as the mice with either of two betaarrestin isoforms knockout appear normal. In order to address the biological function of betaarrestins during developmental process, we generate betaarrestin1/2 double knockout mice. We found that betaarrestin1/2 dual-null mice developed respiratory distress and atelectasis that subsequently caused neonatal death. Morphological examination revealed type II pneumocyte immaturity. Our results indicate that not only betaarrestin1/2 double knockout lung tissue show disturbances in cell proliferation but betaarrestin1 and betaarrestin2 contribute to pulmonary surfactant complex generation during pulmonary maturation. Intra-amniotic delivery of recombinant adenovirus expressing betaarrestin1 or betaarrestin2 enhances surfactant-associated proteins synthesis in vivo. Our mRNA microarray data further reveal that betaarrestin1/2 double knockout results in downregulation of a significant proportion of genes involved in several lung morphogenesis processes. Together, our study demonstrates that betaarrestin1 and betaarrestin2 collaborate in embryonic development processes for epithelial pneumocyte differentiation and lung maturation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1095-564X
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
339
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
407-17
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Loss of betaarrestin1 and betaarrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice.
pubmed:affiliation
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't