Linked Life Data

20059983

Source:http://linkedlifedata.com/resource/pubmed/id/20059983

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-2-22
pubmed:abstractText
Since allopregnanolone (ALLO) elicits anxiolytic-like action and increases neuropeptide Y Y1 (NPY Y1) receptors gene expression in the amygdala, we were interested in studying the involvement of NPY Y1 receptors in the anxiolytic-like actions of ALLO. The anxiety-like behavior was evaluated in mice using Vogel's conflict test (VCT), in which number of shocks were measured. ALLO and NPYergic agents, alone or in combinations, were administered bilaterally into the central nucleus of amygdala (CeA). The intra-CeA administration of ALLO, NPY or NPY Y1/Y5 receptors agonist [Leu(31), Pro(34)]-NPY resulted in dose-dependent increase in the number of shocks in VCT, indicating anxiolytic-like effect. However, opposite effect was observed following administration of selective NPY Y1 receptors antagonist BIBP3226. While prior administration with NPY or [Leu(31), Pro(34)]-NPY, at the subeffective dose, potentiated the ALLO-induced anxiolytic-like effect, the same was antagonized by BIBP3226. Further, the effect of acute ALLO (30 mg/kg, intraperitoneal) on the endogenous NPY system in the CeA, ventral part of lateral division of bed nucleus of the stria terminalis (BSTLV), nucleus accumbens core (AcbC) and arcuate nucleus (ARC) was studied with immunocytochemistry. Acute ALLO treatment significantly decreased the population of NPY-immunoreactive cells in the CeA and also in the ARC. While NPY-immunoreactive fibers were slightly increased in the AcbC and BSTLV, the cells in AcbC and fibers in ARC did not respond. We suggest that NPY may mediate ALLO induced anxiolytic-like behavior in the neuroanatomical framework of the CeA, possibly via NPY Y1 receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1872-6240
pubmed:author
pubmed:copyrightInfo
Copyright 2009 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
8
pubmed:volume
1318
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-86
pubmed:meshHeading
pubmed-meshheading:20059983-Amygdala, pubmed-meshheading:20059983-Animals, pubmed-meshheading:20059983-Anti-Anxiety Agents, pubmed-meshheading:20059983-Arcuate Nucleus, pubmed-meshheading:20059983-Arginine, pubmed-meshheading:20059983-Central Nervous System Agents, pubmed-meshheading:20059983-Diazepam, pubmed-meshheading:20059983-Dose-Response Relationship, Drug, pubmed-meshheading:20059983-Electroshock, pubmed-meshheading:20059983-Immunohistochemistry, pubmed-meshheading:20059983-Male, pubmed-meshheading:20059983-Mice, pubmed-meshheading:20059983-Neuropeptide Y, pubmed-meshheading:20059983-Neuropsychological Tests, pubmed-meshheading:20059983-Nucleus Accumbens, pubmed-meshheading:20059983-Pregnanolone, pubmed-meshheading:20059983-Receptors, Neuropeptide Y, pubmed-meshheading:20059983-Septal Nuclei
pubmed:year
2010
pubmed:articleTitle
Neuropeptide Y Y1 receptors in the central nucleus of amygdala mediate the anxiolytic-like effect of allopregnanolone in mice: Behavioral and immunocytochemical evidences.
pubmed:affiliation
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Nagpur-440 033, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't