Linked Life Data

20059638

Source:http://linkedlifedata.com/resource/pubmed/id/20059638

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-6-15
pubmed:abstractText
Anandamide (AEA), the most extensively studied endocannabinoid, and its putative cannabinoid receptors, CB1 and CB2, exert a variety of physiological and pharmacological effects in chronic liver diseases, such as hyperdynamic circulation. Anandamide selectively blocks proliferation and induces cell death in hepatic stellate cells (HSC), the key cell type of liver fibrogenesis. However, its precise molecular mechanism in rat HSC has not been fully elucidated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, http://linkedlifedata.com/resource/pubmed/chemical/Cnr2 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Polyunsaturated Alkamides, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB1, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB2, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha, http://linkedlifedata.com/resource/pubmed/chemical/anandamide
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1440-1746
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
991-1001
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:20059638-Animals, pubmed-meshheading:20059638-Arachidonic Acids, pubmed-meshheading:20059638-Blotting, Western, pubmed-meshheading:20059638-Cell Line, pubmed-meshheading:20059638-Cell Nucleus Shape, pubmed-meshheading:20059638-Cell Proliferation, pubmed-meshheading:20059638-Cholesterol, pubmed-meshheading:20059638-Dose-Response Relationship, Drug, pubmed-meshheading:20059638-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:20059638-Flow Cytometry, pubmed-meshheading:20059638-Fluorescent Antibody Technique, pubmed-meshheading:20059638-Hepatic Stellate Cells, pubmed-meshheading:20059638-Inflammation Mediators, pubmed-meshheading:20059638-Interleukin-2, pubmed-meshheading:20059638-Interleukin-6, pubmed-meshheading:20059638-Membrane Microdomains, pubmed-meshheading:20059638-Microscopy, Confocal, pubmed-meshheading:20059638-Necrosis, pubmed-meshheading:20059638-Phosphatidylinositol 3-Kinases, pubmed-meshheading:20059638-Polyunsaturated Alkamides, pubmed-meshheading:20059638-Proto-Oncogene Proteins c-akt, pubmed-meshheading:20059638-RNA, Messenger, pubmed-meshheading:20059638-Rats, pubmed-meshheading:20059638-Receptor, Cannabinoid, CB1, pubmed-meshheading:20059638-Receptor, Cannabinoid, CB2, pubmed-meshheading:20059638-Signal Transduction, pubmed-meshheading:20059638-Tumor Necrosis Factor-alpha
pubmed:year
2010
pubmed:articleTitle
Anandamide induces cell death through lipid rafts in hepatic stellate cells.
pubmed:affiliation
Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't