Linked Life Data

2005736

Source:http://linkedlifedata.com/resource/pubmed/id/2005736

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1991-4-24
pubmed:abstractText
We review herein the evidence that estrogen is protective against the development of cardiovascular disease in women. To our knowledge, no studies in women have looked at endogenous estrogen levels as predictors of cardiovascular disease. Studies of surrogate measures of endogenous estrogen such as parity, age at menarche, and age at menopause have provided inconsistent results. Current use of oral contraceptives increases risk in older women who smoke cigarettes, but most studies of past use show no increased risk. Most, but not all, studies of hormone replacement therapy in postmenopausal women show around a 50% reduction in risk of a coronary event in women using unopposed oral estrogen. These important observations need to be confirmed in a double-blind, randomized clinical trial, since the protection is biologically plausible and the magnitude of the benefit would be quite large if selection factors can be excluded.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0098-7484
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
265
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1861-7
pubmed:dateRevised
2006-11-7
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Estrogen and coronary heart disease in women.
pubmed:affiliation
Department of Community and Family Medicine, University of California-San Diego, La Jolla 92093-0607.
pubmed:publicationType
Journal Article, Review