Source:http://linkedlifedata.com/resource/pubmed/id/20054099
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2010-1-7
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| pubmed:abstractText |
We have shown that the K65R resistance mutation in HIV type-1 (HIV-1) reverse transcriptase (RT) is selected more rapidly in subtype C than subtype B HIV-1 in biochemical, cell culture and clinical studies. Template-usage experiments demonstrated that subtype C nucleotide coding sequences caused RT to preferentially pause, leading to K65R acquisition. This new study now further establishes the basis for differential occurrence of both K65R and thymidine analogue mutations (TAMs) between subtypes.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
2040-2066
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
117-31
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| pubmed:meshHeading |
pubmed-meshheading:20054099-Base Sequence,
pubmed-meshheading:20054099-DNA, Viral,
pubmed-meshheading:20054099-Drug Resistance, Viral,
pubmed-meshheading:20054099-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:20054099-HIV Infections,
pubmed-meshheading:20054099-HIV Reverse Transcriptase,
pubmed-meshheading:20054099-HIV-1,
pubmed-meshheading:20054099-Humans,
pubmed-meshheading:20054099-Molecular Sequence Data,
pubmed-meshheading:20054099-Point Mutation,
pubmed-meshheading:20054099-RNA, Viral,
pubmed-meshheading:20054099-Reverse Transcriptase Inhibitors
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| pubmed:year |
2010
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| pubmed:articleTitle |
Factors affecting template usage in the development of K65R resistance in subtype C variants of HIV type-1.
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| pubmed:affiliation |
McGill University AIDS Center, Jewish General Hospital, Montréal, QC, Canada.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|