Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-2-9
pubmed:databankReference
pubmed:abstractText
In the course of studies on human copper-zinc superoxide dismutase (SOD1), we observed a modified form of the protein whose mass was increased by 158 mass units. The covalent modification was characterized, and we established that it is a novel heptasulfane bridge connecting the two Cys111 residues in the SOD1 homodimer. The heptasulfane bridge was visualized directly in the crystal structure of a recombinant human mutant SOD1, H46R/H48Q, produced in yeast. The modification is reversible, with the bridge being cleaved by thiols, by cyanide, and by unfolding of the protein to expose the polysulfane. The polysulfane bridge can be introduced in vitro by incubation of purified SOD1 with elemental sulfur, even under anaerobic conditions and in the presence of a metal chelator. Because polysulfanes and polysulfides can catalyze the generation of reactive oxygen and sulfur species, the modification may endow SOD1 with a toxic gain of function.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-10867014, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-10889018, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-11114261, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-1175624, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-12127151, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-12393927, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-12458194, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-12706500, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-12754496, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-13673028, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-14006352, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-14769017, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-15096637, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-15215895, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-15298006, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-15326189, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-15485869, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-15522970, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-15572765, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-16005218, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-16195234, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-16330499, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-16615773, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-16627692, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-16705654, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-16749017, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-17092942, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-17119635, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-17146286, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-17157186, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-17571177, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-17666395, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-17951430, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-18211954, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-18754702, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-19227972, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-19233858, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-19325915, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-2164216, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-2254318, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-2695062, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-4276457, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-5447431, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-5536559, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-5542679, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-5543955, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-6357923, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-6770891, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-718975, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-7574505, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-7733652, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-7735193, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-8307002, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-8382691, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-8556150, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-8560268, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-8647082, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-8650157, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-9083002, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-9083112, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-9295278, http://linkedlifedata.com/resource/pubmed/commentcorrection/20052996-9871613
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1520-4995
pubmed:author
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
49
pubmed:owner
NLM
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