Source:http://linkedlifedata.com/resource/pubmed/id/20051647
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-5-7
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| pubmed:abstractText |
The association of the FTO gene polymorphism, rs9939609, with obesity was examined using the population of the Takahata study (n (M/F): 2,639 (1,168 / 1,470); age: 63.0 +/- 10.2 years), a Japanese community-based study. The effects of lifestyle-related factors, including nutritional intake and physical activities, on the association were also examined. Body mass index (BMI) was significantly associated with the FTO gene polymorphism (p<0.001). A case-control association study of the FTO gene polymorphism with obesity using multiple logistic regression analysis showed a significant association of the genotype AA (odds ratio, 1.53 [95% confidential interval, 1.04-2.24]) after adjustment for age and gender. Analysis to examine the differences in lifestyle-related factors among the genotype groups showed a significant difference in the energy expenditure for moderate to high-intensity physical activity (PA) (> or = 3.0 METs) (p=0.012) with a significant decrease toward the genotype AA (p=0.027). The effect of energy expenditure for moderate to high-intensity PA on the association of the polymorphism with obesity was then examined using study groups stratified based on the energy expenditure for moderate to high-intensity PA (Low-PA and High-PA). The BMI was significantly higher in the genotype AA in the Low-PA group (p=0.016) but not in the High-PA group (p=0.103). Furthermore, the genotype AA was significantly associated with obesity (odds ratio, 2.39 [95% confidential interval, 1.19-4.80]) in the Low-PA group but not in the High- PA group (p=0.650). The FTO gene, rs9939609, was associated with obesity, and the association was evident in subjects with low-PA, suggesting a PA-dependent association.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1348-4540
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| pubmed:author |
pubmed-author:DaimonMakotoM,
pubmed-author:FukaoAkiraA,
pubmed-author:KamedaWataruW,
pubmed-author:KarasawaShigeruS,
pubmed-author:KatoTakeoT,
pubmed-author:KawataSumioS,
pubmed-author:KayamaTakamasaT,
pubmed-author:KubotaIsaoI,
pubmed-author:MuramatsuMasaakiM,
pubmed-author:OizumiToshihideT,
pubmed-author:SasakiSatoshiS,
pubmed-author:SusaShinjiS,
pubmed-author:ToriyamaSayumiS,
pubmed-author:WadaKirikoK
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
57
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
293-301
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| pubmed:meshHeading |
pubmed-meshheading:20051647-Aged,
pubmed-meshheading:20051647-Body Mass Index,
pubmed-meshheading:20051647-Case-Control Studies,
pubmed-meshheading:20051647-Cross-Sectional Studies,
pubmed-meshheading:20051647-Diet,
pubmed-meshheading:20051647-Energy Intake,
pubmed-meshheading:20051647-Energy Metabolism,
pubmed-meshheading:20051647-Female,
pubmed-meshheading:20051647-Genotype,
pubmed-meshheading:20051647-Humans,
pubmed-meshheading:20051647-Japan,
pubmed-meshheading:20051647-Life Style,
pubmed-meshheading:20051647-Logistic Models,
pubmed-meshheading:20051647-Male,
pubmed-meshheading:20051647-Middle Aged,
pubmed-meshheading:20051647-Obesity,
pubmed-meshheading:20051647-Odds Ratio,
pubmed-meshheading:20051647-Physical Exertion,
pubmed-meshheading:20051647-Polymorphism, Genetic,
pubmed-meshheading:20051647-Proteins
|
| pubmed:year |
2010
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| pubmed:articleTitle |
Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population.
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| pubmed:affiliation |
Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|