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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-3-31
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pubmed:abstractText |
In search for new sources of mesenchymal stem cells (MSCs) for renal repair in acute kidney injury (AKI), we investigated the potential of human cord blood (CB)-MSCs to cure mice with AKI. Infusion of CB-MSCs in immunodeficient mice with cisplatin-induced AKI ameliorated both renal function and tubular cell injury, and prolonged survival. Transplanted CB-MSCs localized in peritubular areas, limited capillary alterations and neutrophil infiltration. Apoptosis reduced and tubular cell proliferation increased by virtue of stem cell capacity to produce growth factors. The reno-protective effect of CB-MSCs was further confirmed by their ability to inhibit oxidative damage and to induce the prosurvival factor Akt in tubular cells. The evidence that CB-MSCs in vitro increased the production of growth factors and inhibited IL-1 beta and TNFalpha synthesis when cocultured with damaged proximal tubular cells indicates a regenerative and anti-inflammatory action of stem cell treatment. Altogether these results highlight the potential of human CB-MSCs as future cell therapy for testing in human AKI.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1549-4918
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pubmed:author |
pubmed-author:AbbateMauroM,
pubmed-author:BenigniArielaA,
pubmed-author:CapelliChiaraC,
pubmed-author:CassisPaolaP,
pubmed-author:ImbertiBarbaraB,
pubmed-author:IntronaMartinoM,
pubmed-author:LazzariLorenzaL,
pubmed-author:Lo CiceroVivianaV,
pubmed-author:LongarettiLorenaL,
pubmed-author:MontelaticiElisaE,
pubmed-author:MontemurroTizianaT,
pubmed-author:MorigiMarinaM,
pubmed-author:RebullaPaoloP,
pubmed-author:RemuzziGiuseppeG,
pubmed-author:RotaCinziaC,
pubmed-author:ZojaCarlaC
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pubmed:issnType |
Electronic
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pubmed:day |
31
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
513-22
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pubmed:meshHeading |
pubmed-meshheading:20049901-Acute Disease,
pubmed-meshheading:20049901-Animals,
pubmed-meshheading:20049901-Anti-Inflammatory Agents,
pubmed-meshheading:20049901-Apoptosis,
pubmed-meshheading:20049901-Cell Culture Techniques,
pubmed-meshheading:20049901-Cell Differentiation,
pubmed-meshheading:20049901-Cell Proliferation,
pubmed-meshheading:20049901-Coculture Techniques,
pubmed-meshheading:20049901-Cord Blood Stem Cell Transplantation,
pubmed-meshheading:20049901-Cytokines,
pubmed-meshheading:20049901-Disease Models, Animal,
pubmed-meshheading:20049901-Female,
pubmed-meshheading:20049901-Graft Survival,
pubmed-meshheading:20049901-Humans,
pubmed-meshheading:20049901-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:20049901-Kidney,
pubmed-meshheading:20049901-Kidney Diseases,
pubmed-meshheading:20049901-Kidney Tubules,
pubmed-meshheading:20049901-Mesenchymal Stem Cell Transplantation,
pubmed-meshheading:20049901-Mesenchymal Stem Cells,
pubmed-meshheading:20049901-Mice,
pubmed-meshheading:20049901-Mice, SCID,
pubmed-meshheading:20049901-Oxidative Stress,
pubmed-meshheading:20049901-Proto-Oncogene Proteins c-akt
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pubmed:year |
2010
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pubmed:articleTitle |
Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury.
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pubmed:affiliation |
Mario Negri Institute for Pharmacological Research, Bergamo, Italy. morigi@marionegri.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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