| pubmed-article:20047977 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20047977 | lifeskim:mentions | umls-concept:C1513822 | lld:lifeskim |
| pubmed-article:20047977 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20047977 | lifeskim:mentions | umls-concept:C1880171 | lld:lifeskim |
| pubmed-article:20047977 | lifeskim:mentions | umls-concept:C0024320 | lld:lifeskim |
| pubmed-article:20047977 | lifeskim:mentions | umls-concept:C0024305 | lld:lifeskim |
| pubmed-article:20047977 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:20047977 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:20047977 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20047977 | pubmed:dateCreated | 2010-1-21 | lld:pubmed |
| pubmed-article:20047977 | pubmed:abstractText | In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF -308G>A (rs1800629), lymphotoxin-alpha (LTA) 252A>G (rs909253), IL10 -3575T>A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain containing 2 (NOD2) 3020insC (rs2066847) genes. Odds ratios were estimated for non-Hispanic whites and several ethnic subgroups using 2-sided tests. Consistent with previous findings, odds ratios were increased for "new" participant TNF -308A carriers (NHL: per-allele odds ratio (OR(allelic)) = 1.10, P(trend) = 0.001; diffuse large B-cell lymphoma (DLBCL): OR(allelic) = 1.23, P(trend) = 0.004). In the combined population, odds ratios were increased for TNF -308A carriers (NHL: OR(allelic) = 1.13, P(trend) = 0.0001; DLBCL: OR(allelic) = 1.25, P(trend) = 3.7 x 10(-6); marginal zone lymphoma: OR(allelic) = 1.35, P(trend) = 0.004) and LTA 252G carriers (DLBCL: OR(allelic) = 1.12, P(trend) = 0.006; mycosis fungoides: OR(allelic) = 1.44, P(trend) = 0.015). The LTA 252A>G/TNF -308G>A haplotype containing the LTA/TNF variant alleles was strongly associated with DLBCL (P = 2.9 x 10(-8)). Results suggested associations between IL10 -3575T>A and DLBCL (P(trend) = 0.02) and IL10 -1082A>G and mantle cell lymphoma (P(trend) = 0.04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology. | lld:pubmed |
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| pubmed-article:20047977 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20047977 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20047977 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20047977 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20047977 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20047977 | pubmed:issn | 1476-6256 | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:HollyElizabet... | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:BrennanPaulP | lld:pubmed |
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| pubmed-article:20047977 | pubmed:author | pubmed-author:RomanEveE | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:CerhanJames... | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:SmithAlexA | lld:pubmed |
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| pubmed-article:20047977 | pubmed:author | pubmed-author:RothmanNathan... | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:ChanockStephe... | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:ZhangLuopingL | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:SmithMartyn... | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:BracciPaige... | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:LinetMartha... | lld:pubmed |
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| pubmed-article:20047977 | pubmed:author | pubmed-author:CoccoPierluig... | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:CozenWendyW | lld:pubmed |
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| pubmed-article:20047977 | pubmed:author | pubmed-author:HartgePatrici... | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:SkibolaChrist... | lld:pubmed |
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| pubmed-article:20047977 | pubmed:author | pubmed-author:SpinelliJohn... | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:ZhengTongzhan... | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:ZhangYaweiY | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:LanQingQ | lld:pubmed |
| pubmed-article:20047977 | pubmed:author | pubmed-author:KrickerAnneA | lld:pubmed |
