Linked Life Data

20047335

Source:http://linkedlifedata.com/resource/pubmed/id/20047335

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-1-26
pubmed:abstractText
When raw diamond nanoparticles (Dnp, 7 nm average particle size) obtained from detonation are submitted to harsh Fenton-treatment, the resulting material becomes free of amorphous soot matter and the process maintains the crystallinity, reduces the particle size (4 nm average particle size), increases the surface OH population, and increases water solubility. All these changes are beneficial for subsequent Dnp covalent functionalization and for the ability of Dnp to cross cell membranes. Fenton-treated Dnps have been functionalized with thionine and the resulting sample has been observed in HeLa cell nuclei. A triethylammonium-functionalized Dnp pairs electrostatically with a plasmid having the green fluorescent protein gene and acts as gene delivery system permitting the plasmid to cross HeLa cell membrane, something that does not occur for the plasmid alone without assistance of polycationic Dnp.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1936-086X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
26
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-74
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Fenton-treated functionalized diamond nanoparticles as gene delivery system.
pubmed:affiliation
Instituto de Tecnologia Quimica CSIC-UPV and Departamento de Quimica, Universidad Politecnica de Valencia, Av de los Naranjos s/n, 46022 Valencia, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't