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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-4-1
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pubmed:abstractText |
The use of delivery templates makes it possible to fabricate shaped, millimeter-thick heterogeneously patterned films of ionotropic hydrogels. These structures include two-dimensional (2-D) patterns of a polymer cross-linked by different ions (e.g., alginic acid cross-linked with Ca2+ and Fe3+) and patterns of step gradients in the concentration of a single cross-linking ion. The delivery templates consist of stacked sheets of chromatography paper patterned with hydrophobic barriers (waterproof tape, transparency film, or toner deposited by a color laser printer). Each layer of paper serves as a reservoir for a different solution of cross-linking ions, while the hydrophobic barriers prevent solutions on adjacent sheets from mixing. Holes cut through the sheets expose different solutions of cross-linking ions to the surface of the templates. Films with shaped regions of hydrogels cross-linked by paramagnetic ions can be oriented with a bar magnet. Variations in the concentrations of cations used to cross-link the gel can control the mechanical properties of the film: for single alginate films composed of areas cross-linked with different concentrations of Fe3+, the regions cross-linked with high concentrations of Fe3+ are more rigid than regions cross-linked with low concentrations of Fe3+. The heterogeneous hydrogel films can be used to culture bacteria in various 2-D designs. The pattern of toxic and nontoxic ions used to cross-link the polymer determines the pattern of viable colonies of Escherichia coli within the film.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-10334980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-10471979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-11565080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-11932229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-12149954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-1366500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-15040259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-15193324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-15378052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-15766388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-15835990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-15986641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-16114956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-16771645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-17169836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-17211899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-18407617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-2848555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-5658571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-5658572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-8809760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-9172409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-9220008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-9283036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-9855189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20046855-9923680
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1944-8244
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1807-12
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:20046855-Alginates,
pubmed-meshheading:20046855-Bacteria,
pubmed-meshheading:20046855-Calcium,
pubmed-meshheading:20046855-Carrageenan,
pubmed-meshheading:20046855-Cross-Linking Reagents,
pubmed-meshheading:20046855-Equipment Design,
pubmed-meshheading:20046855-Escherichia coli,
pubmed-meshheading:20046855-Gels,
pubmed-meshheading:20046855-Hydrogels,
pubmed-meshheading:20046855-Ions,
pubmed-meshheading:20046855-Iron,
pubmed-meshheading:20046855-Metals,
pubmed-meshheading:20046855-Surface Properties,
pubmed-meshheading:20046855-Temperature
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pubmed:year |
2009
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pubmed:articleTitle |
Heterogeneous films of ionotropic hydrogels fabricated from delivery templates of patterned paper.
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pubmed:affiliation |
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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