20045424

Source:http://linkedlifedata.com/resource/pubmed/id/20045424

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0018284, umls-concept:C0026336, umls-concept:C0035372, umls-concept:C0542341, umls-concept:C0728831, umls-concept:C1516691, umls-concept:C1522424
pubmed:issue	3
pubmed:dateCreated	2010-4-26
pubmed:abstractText	Rett syndrome (RTT) is an autism-spectrum disorder caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). Abnormalities in social behavior, stereotyped movements, and restricted interests are common features in both RTT and classic autism. While mouse models of both RTT and autism exist, social behaviors have not been explored extensively in mouse models of RTT. Here, we report cognitive and social abnormalities in Mecp2(1lox) null mice, an animal model of RTT. The null mice show severe deficits in short- and long-term object recognition memories, reminiscent of the severe cognitive deficits seen in RTT girls. Social behavior, however, is abnormal in that the null mice spend more time in contact with stranger mice than do wildtype controls. These findings are consistent with reports of increased reciprocal social interaction in RTT girls relative to classic autism. We also report here that the levels of the neurotrophins brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and nerve growth factor (NGF) are decreased in the hippocampus of the null mice, and discuss how this may provide an underlying mechanism for both the cognitive deficits and the increased motivation for social contact observed in the Mecp2(1lox) null mice. These studies support a differential etiology between RTT and autism, particularly with respect to sociability deficits.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0151504
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor, http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I, http://linkedlifedata.com/resource/pubmed/chemical/Methyl-CpG-Binding Protein 2, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factor
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	1873-507X
pubmed:author	pubmed-author:Berger-SweeneyJoanneJ, pubmed-author:MellotTiffany JTJ, pubmed-author:MoriuchiJennifer MJM, pubmed-author:NagNupurN, pubmed-author:SchaevitzLaura RLR
pubmed:copyrightInfo	Copyright 2009 Elsevier Inc. All rights reserved.
pubmed:issnType	Electronic
pubmed:day	1
pubmed:volume	100
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	255-63
pubmed:meshHeading	pubmed-meshheading:20045424-Animals, pubmed-meshheading:20045424-Brain-Derived Neurotrophic Factor, pubmed-meshheading:20045424-Cognition, pubmed-meshheading:20045424-Disease Models, Animal, pubmed-meshheading:20045424-Hippocampus, pubmed-meshheading:20045424-Insulin-Like Growth Factor I, pubmed-meshheading:20045424-Male, pubmed-meshheading:20045424-Methyl-CpG-Binding Protein 2, pubmed-meshheading:20045424-Mice, pubmed-meshheading:20045424-Mice, Inbred C57BL, pubmed-meshheading:20045424-Mice, Knockout, pubmed-meshheading:20045424-Mutation, pubmed-meshheading:20045424-Nerve Growth Factor, pubmed-meshheading:20045424-Recognition (Psychology), pubmed-meshheading:20045424-Rett Syndrome, pubmed-meshheading:20045424-Social Behavior
pubmed:year	2010
pubmed:articleTitle	Cognitive and social functions and growth factors in a mouse model of Rett syndrome.
pubmed:affiliation	Department of Biological Sciences, Wellesley College, Wellesley MA 02481, United States.
pubmed:publicationType	Journal Article