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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-4-26
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pubmed:abstractText |
The gastric epithelium genome undergoes extensive epigenetic alterations during Helicobacter pylori-induced gastritis. Expression of the gene encoding the DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) might be reduced via hypermethylation of its promoter in patients with H pylori gastritis. We characterized expression of MGMT and its epigenetic regulation via CpG methylation in gastric tissue from patients with H pylori gastritis and investigated the effects of H pylori infection eradication on MGMT expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Modification Methylases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Repair Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/MGMT protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/cagA protein, Helicobacter pylori
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1836-44
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pubmed:meshHeading |
pubmed-meshheading:20044995-Adult,
pubmed-meshheading:20044995-Aged,
pubmed-meshheading:20044995-Aged, 80 and over,
pubmed-meshheading:20044995-Anti-Bacterial Agents,
pubmed-meshheading:20044995-Antigens, Bacterial,
pubmed-meshheading:20044995-Bacterial Proteins,
pubmed-meshheading:20044995-Biopsy,
pubmed-meshheading:20044995-Case-Control Studies,
pubmed-meshheading:20044995-Cell Line,
pubmed-meshheading:20044995-CpG Islands,
pubmed-meshheading:20044995-DNA Methylation,
pubmed-meshheading:20044995-DNA Modification Methylases,
pubmed-meshheading:20044995-DNA Repair,
pubmed-meshheading:20044995-DNA Repair Enzymes,
pubmed-meshheading:20044995-Down-Regulation,
pubmed-meshheading:20044995-Epigenesis, Genetic,
pubmed-meshheading:20044995-Female,
pubmed-meshheading:20044995-Gastric Mucosa,
pubmed-meshheading:20044995-Gastritis,
pubmed-meshheading:20044995-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:20044995-Helicobacter Infections,
pubmed-meshheading:20044995-Helicobacter pylori,
pubmed-meshheading:20044995-Humans,
pubmed-meshheading:20044995-Male,
pubmed-meshheading:20044995-Middle Aged,
pubmed-meshheading:20044995-Mutagenesis,
pubmed-meshheading:20044995-Promoter Regions, Genetic,
pubmed-meshheading:20044995-RNA, Messenger,
pubmed-meshheading:20044995-Treatment Outcome,
pubmed-meshheading:20044995-Tumor Suppressor Proteins,
pubmed-meshheading:20044995-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
CpG methylation and reduced expression of O6-methylguanine DNA methyltransferase is associated with Helicobacter pylori infection.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. asepu@mail.med.upenn.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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