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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-2-23
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pubmed:abstractText |
The potassium chloride cotransporter 2 (KCC2) is the main neuronal chloride extruder in the adult nervous system. Therefore, KCC2 is responsible for an inwardly directed electrochemical gradient of chloride that leads to hyperpolarizing GABA-mediated responses. Under some pathophysiological conditions, GABA has been reported to be depolarizing because of a downregulation of KCC2. This is the first study to our knowledge analyzing the expression of KCC2 after a focal cerebral ischemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e151-9
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pubmed:meshHeading |
pubmed-meshheading:20044519-Animals,
pubmed-meshheading:20044519-Chlorides,
pubmed-meshheading:20044519-Down-Regulation,
pubmed-meshheading:20044519-Ischemic Attack, Transient,
pubmed-meshheading:20044519-Male,
pubmed-meshheading:20044519-Potassium,
pubmed-meshheading:20044519-RNA, Messenger,
pubmed-meshheading:20044519-Rats,
pubmed-meshheading:20044519-Rats, Wistar,
pubmed-meshheading:20044519-Symporters,
pubmed-meshheading:20044519-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Downregulation of potassium chloride cotransporter KCC2 after transient focal cerebral ischemia.
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pubmed:affiliation |
Hans-Berger Clinic for Neurology, Friedrich-Schiller University, Erlanger Allee 101, 07747 Jena, Germany. christiane.frahm@med.uni-jena.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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