Linked Life Data

20044037

Source:http://linkedlifedata.com/resource/pubmed/id/20044037

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2010-4-5
pubmed:abstractText
Extracellular matrix components can influence cell behaviour by modulating a wide variety of events. In particular, the glycosaminoglycan hyaluronan is involved in many processes of the normal and pathological adult cells and it is essential for embryonic development. Two main HA receptors have been characterized in vertebrate developing embryos: CD44 and RHAMM. These receptors display completely different characteristics apart from their ability to bind hyaluronan. RHAMM is still the most mysterious hyaluronan receptor as it can act as cell surface receptor but it can also be localized in the cytoplasm or in the cell nucleus, displaying both hyaluronan dependent and independent functions. In particular, the role of RHAMM during embryogenesis is still largely unclear. We reported a detailed gene expression analysis of RHAMM during Xenopus laevis development comparing its mRNA distribution with that of the hyaluronan synthases and CD44 genes, in order to provide a first insight into the possible role of RHAMM during vertebrate embryogenesis. Our findings point out that RHAMM mRNA displays a specific distribution in proliferating regions of the developing neural tube and retina where synthesis of hyaluronan is not detected. On the contrary, RHAMM expression correlates with the expression of hyaluronan synthase-1 and hyaluronan-receptor CD44 gene expression in migrating cranial neural crest. These results suggest that during the central nervous system development RHAMM could be involved in cell proliferation and migration processes both in a hyaluronan independent and dependent manner.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1872-7298
pubmed:author
pubmed:copyrightInfo
Copyright 2009 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-7
pubmed:meshHeading
pubmed:articleTitle
RHAMM mRNA expression in proliferating and migrating cells of the developing central nervous system.
pubmed:affiliation
Unit of Cell and Developmental Biology, Department of Biology, University of Pisa, S.S.12 Abetone e Brennero 4, I-56127 Pisa, Italy.
pubmed:publicationType
Journal Article