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rdf:type |
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lifeskim:mentions |
umls-concept:C0037083,
umls-concept:C0079904,
umls-concept:C0334227,
umls-concept:C0449432,
umls-concept:C1166825,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1710082,
umls-concept:C1826565,
umls-concept:C1998811
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pubmed:issue |
4
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pubmed:dateCreated |
2010-2-15
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pubmed:abstractText |
RKIP was first identified as an inhibitor of the Raf-MEK-ERK signaling pathway. RKIP was also found to play an important role in the NF-kappaB pathway. Genetic and biochemical studies demonstrated that RKIP functioned as a scaffold protein facilitating the phosphorylation of IkappaB by upstream kinases. However, contrary to what one would expect of a scaffold protein, our results show that RKIP has an overall inhibitory effect on the NF-kappaB transcriptional activities. Since NF-kappaB target gene expression is subject to negative regulation involving the optimal induction of negative regulators, our data support a hypothesis that RKIP inhibits NF-kappaB activity via the auto-regulatory feedback loop by rapidly inducing the expression and synthesis of inhibitors of NF-kappaB activation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1 Receptor-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/MAP kinase kinase kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/PEBP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylethanolamine Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/TNF Receptor-Associated Factor 6
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1873-3468
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
584
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
662-8
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:20043910-Animals,
pubmed-meshheading:20043910-COS Cells,
pubmed-meshheading:20043910-Cell Line,
pubmed-meshheading:20043910-Cell Line, Tumor,
pubmed-meshheading:20043910-Cercopithecus aethiops,
pubmed-meshheading:20043910-Gene Expression,
pubmed-meshheading:20043910-Humans,
pubmed-meshheading:20043910-I-kappa B Kinase,
pubmed-meshheading:20043910-I-kappa B Proteins,
pubmed-meshheading:20043910-Immunoblotting,
pubmed-meshheading:20043910-Immunoprecipitation,
pubmed-meshheading:20043910-Interleukin-1 Receptor-Associated Kinases,
pubmed-meshheading:20043910-Interleukin-1beta,
pubmed-meshheading:20043910-MAP Kinase Kinase Kinases,
pubmed-meshheading:20043910-NF-kappa B,
pubmed-meshheading:20043910-Neoplasms,
pubmed-meshheading:20043910-Phosphatidylethanolamine Binding Protein,
pubmed-meshheading:20043910-Phosphorylation,
pubmed-meshheading:20043910-Protein Binding,
pubmed-meshheading:20043910-RNA Interference,
pubmed-meshheading:20043910-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20043910-Signal Transduction,
pubmed-meshheading:20043910-TNF Receptor-Associated Factor 6,
pubmed-meshheading:20043910-Ubiquitination
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pubmed:year |
2010
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pubmed:articleTitle |
RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex.
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pubmed:affiliation |
Department of Biochemistry and Cancer Biology, College of Medicine, University of Toledo, Toledo, OH 43614-5804, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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