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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-1-20
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pubmed:abstractText |
Analyses of Expressed Sequence Tags (ESTs) databases suggest that most human genes have multiple alternative splice variants. The alternative splicing of pre-mRNA is tightly regulated during development and in different tissue types. Changes in splicing patterns have been described in disease states. Recently, we used whole-transcriptome shotgun pryrosequencing to characterize 4 malignant pleural mesothelioma (MPM) tumors, 1 lung adenocarcinoma and 1 normal lung. We hypothesized that alternative splicing profiles might be detected in the sequencing data for the expressed genes in these samples.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20043850-10766169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20043850-11172613,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2350
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
149
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:20043850-Alternative Splicing,
pubmed-meshheading:20043850-Databases, Genetic,
pubmed-meshheading:20043850-Expressed Sequence Tags,
pubmed-meshheading:20043850-Gene Expression Profiling,
pubmed-meshheading:20043850-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20043850-Humans,
pubmed-meshheading:20043850-Mesothelioma,
pubmed-meshheading:20043850-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:20043850-Pleural Neoplasms,
pubmed-meshheading:20043850-RNA Precursors,
pubmed-meshheading:20043850-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20043850-Sequence Analysis, RNA
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pubmed:year |
2009
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pubmed:articleTitle |
Differentially expressed alternatively spliced genes in malignant pleural mesothelioma identified using massively parallel transcriptome sequencing.
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pubmed:affiliation |
The Thoracic Surgery Oncology Laboratory and Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ldong@partners.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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