Linked Life Data

200437

Source:http://linkedlifedata.com/resource/pubmed/id/200437

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1978-1-27
pubmed:abstractText
The central hypotensive activity of clonidine and of 12 structurally related analogues was determined following intravenous administration to pentobarbital-anaesthetized, normotensive rats. This sympathoinhibitory action was characterized by means of a pC30, calculated from dose-response curves. The centrally mediated depressor activity (pC30) was correlated with the peripherally induced pressor activity of the compounds (pC100) reported on previously and which had been established after intravenous application to pithed rats. In these correlations, the quantitative ability of the substances to penetrate into the central nervous system had been taken into account. The octanol/buffer (pH = 7.4) partition coefficients were used as a measure of lipophilic behaviour. A positive correlation was found between the central hypotensive activity and the linear combination of peripheral alpha-sympathomimetic activity and lipophilicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
229-36
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Central and peripheral alpha-adrenergic effects of some imidazolidines.
pubmed:publicationType
Journal Article