Linked Life Data

20042358

Source:http://linkedlifedata.com/resource/pubmed/id/20042358

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-3-15
pubmed:abstractText
Materials obtained by the synergistic combination of nanotechnology and biomedicine are an important source of drug delivery and other health care related applications. The anchoring of amino acids onto the surface of nano-sized magnetite is one such example. Herein, we report on the binding of a semi-essential amino acid, L-arginine, onto the surface of nano magnetite, creating a stable aqueous suspension by an in situ one-step method using sonochemical synthesis. An ex situ two-step process was also attempted, but was soon discarded owing to the relative short duration of the suspension attributed to increase in particle size and lower extent of binding. The initial concentration of the amino acid was found to play an important role in controlling the particle size and also the binding motif. Lower concentrations of arginine were found to favor the formation of elongated tubular structures, while at higher concentrations, the elongated structures were less prominent and arginine was found to be adsorbed onto the surface of the magnetite. This surface-functionalized nanomagnetite with amino acids could become a promising vehicle for drug delivery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-2828
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2009 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
730-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Sonochemical stabilization of ultrafine colloidal biocompatible magnetite nanoparticles using amino acid, L-arginine, for possible bio applications.
pubmed:affiliation
Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology, Bombay, Mumbai 400 076, India.
pubmed:publicationType
Journal Article