Linked Life Data

20042344

Source:http://linkedlifedata.com/resource/pubmed/id/20042344

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-2-3
pubmed:abstractText
Inactive compounds like autofluorescent proteins can absorb visible daylight (around 500-700 nm) and can emit active electrons producing reactive oxygen species (ROS) leading to an increase in photokilling processes in bacteria. The endogenously originated ROS create single strand breaks in the cells DNA. These various types of breaks can be partially repaired by different cellular repair systems but a high number of breaks leads to cell death. A dramatic increase in cell killing can be observed from green, via yellow to red color emission. This was tested by colony forming ability. The generation of ROS and the bacterial protection mechanisms are discussed. We outline some possibilities for use the protein's properties for treatment of antibiotic multi-resistant and difficult to treat bacteria like the methicillin-resistant Staphylococcus aureus (MRSA).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1873-2682
pubmed:author
pubmed:copyrightInfo
Copyright 2009 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-8
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
From green to red--To more dead? Autofluorescent proteins as photosensitizers.
pubmed:affiliation
German Cancer Research Center, Division of Biophysics of Macromolecules, INF 580, D-69120 Heidelberg, Germany.
pubmed:publicationType
Journal Article