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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-1-21
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pubmed:abstractText |
Epigenetic silencing of tumor suppressor genes associated with promoter methylation is considered to be a hallmark of oncogenesis. RASSF1A is a candidate tumor suppressor gene which was found to be inactivated in many human cancers. Although we have had a preliminary cognition about the function of RASSF1A, the exact mechanisms about how RASSF1A functions in human cancers were largely unknown. Moreover, the effect of mutated K-Ras gene on the function of RASSF1A is lacking. The aim of this study was to investigate the expression profile and methylation status of RASSF1A gene, and to explore its concrete mechanisms as a tumor suppressor gene in Nasopharyngeal Carcinoma.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1756-9966
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
160
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:20042089-Apoptosis,
pubmed-meshheading:20042089-Blotting, Western,
pubmed-meshheading:20042089-Carcinoma,
pubmed-meshheading:20042089-Cell Separation,
pubmed-meshheading:20042089-DNA Methylation,
pubmed-meshheading:20042089-Flow Cytometry,
pubmed-meshheading:20042089-Gene Expression,
pubmed-meshheading:20042089-Gene Expression Profiling,
pubmed-meshheading:20042089-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20042089-Gene Silencing,
pubmed-meshheading:20042089-Genes, ras,
pubmed-meshheading:20042089-Humans,
pubmed-meshheading:20042089-Nasopharyngeal Neoplasms,
pubmed-meshheading:20042089-Promoter Regions, Genetic,
pubmed-meshheading:20042089-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20042089-Tumor Suppressor Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinoma.
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pubmed:affiliation |
Cancer Center of Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. wangtaowh@yahoo.com.cn
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pubmed:publicationType |
Journal Article
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