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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-12-31
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pubmed:abstractText |
Inhibition of the T-cell-mediated immune response is a necessary component of preventing rejection following xenotransplantation with pig alpha1,3-galactosyltransferase gene-knockout (GTKO) organs. Cytotoxic T lymphocyte-associated antigen (CTLA4) is a co-stimulatory molecule that inhibits T-cell activity and may be useful in prolonging graft rejection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1399-3089
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pubmed:author |
pubmed-author:AyaresDavid LDL,
pubmed-author:BallSuyapa FSF,
pubmed-author:CooperDavid K CDK,
pubmed-author:DandroAmy SAS,
pubmed-author:MendicinoMichaelM,
pubmed-author:MonahanJeffrey AJA,
pubmed-author:PhelpsCarol JCJ,
pubmed-author:RamsoondarJagdeece JJJ,
pubmed-author:VanceAmy MAM,
pubmed-author:VaughtTodd DTD,
pubmed-author:WaltersAnneke HAH,
pubmed-author:WellsKevin DKD
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
477-85
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pubmed:dateRevised |
2010-10-25
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pubmed:meshHeading |
pubmed-meshheading:20042047-Animals,
pubmed-meshheading:20042047-Animals, Genetically Modified,
pubmed-meshheading:20042047-Female,
pubmed-meshheading:20042047-Humans,
pubmed-meshheading:20042047-Immunity, Humoral,
pubmed-meshheading:20042047-Immunoconjugates,
pubmed-meshheading:20042047-Immunoglobulin G,
pubmed-meshheading:20042047-Immunosuppressive Agents,
pubmed-meshheading:20042047-Nuclear Transfer Techniques,
pubmed-meshheading:20042047-Pregnancy,
pubmed-meshheading:20042047-Recombinant Fusion Proteins,
pubmed-meshheading:20042047-Sheep,
pubmed-meshheading:20042047-Swine,
pubmed-meshheading:20042047-Tissue Distribution,
pubmed-meshheading:20042047-Transgenes,
pubmed-meshheading:20042047-Transplantation, Heterologous
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pubmed:articleTitle |
Production and characterization of transgenic pigs expressing porcine CTLA4-Ig.
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pubmed:affiliation |
Revivicor, Inc, Blacksburg, VA 24060, USA.
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pubmed:publicationType |
Journal Article
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