Source:http://linkedlifedata.com/resource/pubmed/id/20040331
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2009-12-30
|
| pubmed:abstractText |
Drug-resistant chronic temporal lobe epilepsy is the most common type of epilepsy that undergoes surgical treatment. To verify if dentate gyrus alterations may play a role in patients with mesial temporal sclerosis (MTS), 14 patients, submitted to epilepsy surgery, were selected. Only cases with MTS alone were included. Granule cell dispersion (GCD) was observed in 7 cases (50%). A statistically significant correlation between GCD and the mean number of seizures/month was evidenced. The percentage of patients who did not achieve seizure relief (i.e. they were not in Engel class 1A) was 57.14% in patients without GCD, whereas that percentage dropped to 14.29% in patients with GCD. The association between a more favorable postsurgical epileptogenic outcome and granule cell pathology in patients with MTS has been observed, thus suggesting that dentate gyrus alterations may play a role in drug-resistant TLE.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0722-5091
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
32-5
|
| pubmed:meshHeading |
pubmed-meshheading:20040331-Adult,
pubmed-meshheading:20040331-Antigens, Nuclear,
pubmed-meshheading:20040331-Brain Diseases,
pubmed-meshheading:20040331-Dentate Gyrus,
pubmed-meshheading:20040331-Epilepsy,
pubmed-meshheading:20040331-Female,
pubmed-meshheading:20040331-Hippocampus,
pubmed-meshheading:20040331-Humans,
pubmed-meshheading:20040331-Male,
pubmed-meshheading:20040331-Middle Aged,
pubmed-meshheading:20040331-Nerve Tissue Proteins,
pubmed-meshheading:20040331-Neurons,
pubmed-meshheading:20040331-Sclerosis,
pubmed-meshheading:20040331-Seizures,
pubmed-meshheading:20040331-Severity of Illness Index,
pubmed-meshheading:20040331-Temporal Lobe,
pubmed-meshheading:20040331-Treatment Outcome,
pubmed-meshheading:20040331-Young Adult
|
| pubmed:articleTitle |
Role of dentate gyrus alterations in mesial temporal sclerosis.
|
| pubmed:affiliation |
Section of Pathology, Department of Hematology and Oncology of the University of Bologna, Bologna, Italy. gianluca.marucci@ausl.bologna.it
|
| pubmed:publicationType |
Journal Article
|