Linked Life Data

20040307

Source:http://linkedlifedata.com/resource/pubmed/id/20040307

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-12-30
pubmed:abstractText
Endocytosis is the process by which extracellular molecules are captured by the cell surface membrane and then taken up into the cell. Once inside the cell, the internalized material is delivered to its final destination via a complex system of organelles, termed the endosomal network. These heterogeneous structures play a key role in the delivery of extracellular and cellular material towards the lysosome for macromolecular degradation. The internalization of mannose-6-phosphate receptors at the cell surface, and their subsequent delivery to the late endosome, is the basis of enzyme replacement therapy in patients with lysosomal storage diseases (LSDs). This review describes the characteristics of the endosomal network and discusses how disturbances in vesicular trafficking or intracellular signaling may be important in the pathology of LSDs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0946-1965
pubmed:author
pubmed:issnType
Print
pubmed:volume
47 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S9-17
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The endosomal network.
pubmed:affiliation
Molecular Medicine Sector, Sansom Institute, School of Pharmacy and Medical Science, University of South Australia, Adelaide, Australia. doug.brooks@unisa.edu.au
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't