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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-4-22
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pubmed:abstractText |
Thirty-four patients with progressive low grade non-Hodgkin's lymphoma were treated with 1 microgram oral alfacalcidol daily. Complete response was seen in four patients and a partial response in four patients with an overall response rate of 24%. Median duration of response was 14 months. Disease stabilised in ten other patients (29%) and 16 patients (47%) had tumour progression. In the sub-group of patients with follicular, small-cleaved cell-lymphoma the overall response to treatment was 29%. Apart from one patient who had a mild transitory elevation of serum calcium there was no recorded toxicity from alfacidol. These results indicate that alfacalcidol has significant antitumour activity in patients with low grade non-Hodgkin's lymphoma of the follicular, small-cleaved cell type.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-1030780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-1089470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-2829219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-2996693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-3024816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-3027709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-3110950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-3754600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-6257495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-6277475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-6310748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-6427926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-6548796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-6611355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-6895862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2003990-7459811
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0007-0920
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
463-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1991
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pubmed:articleTitle |
Alfacalcidol is a nontoxic, effective treatment of follicular small-cleaved cell lymphoma.
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pubmed:affiliation |
Department of Medical Oncology, Glasgow Royal Infirmary, UK.
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pubmed:publicationType |
Journal Article
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