Linked Life Data

20038637

Source:http://linkedlifedata.com/resource/pubmed/id/20038637

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-1-21
pubmed:abstractText
The broad-complex tramtrack and bric a brac-zinc finger transcriptional regulator (BTB-ZF), promyelocytic leukemia zinc finger (PLZF), was recently shown to control the development of the characteristic innate T cell phenotype and effector functions of NK T cells. Interestingly, the ectopic expression of PLZF was shown to push conventional T cells into an activated state that seems to be proinflammatory. The factors that control the normal expression of PLZF in lymphocytes are unknown. In this study, we show that PLZF expression is not restricted to NK T cells but is also expressed by a subset of gammadelta T cells, functionally defining distinct subsets of this innate T cell population. A second BTB-ZF gene, ThPOK, is important for the phenotype of the PLZF-expressing gammadelta T cells. Most importantly, TCR signal strength and expression of inhibitor of differentiation gene 3 control the frequency of PLZF-expressing gammadelta T cells. This study defines the factors that control the propensity of the immune system to produce potentially disease-causing T cell subsets.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1550-6606
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
184
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1268-79
pubmed:meshHeading
pubmed-meshheading:20038637-Animals, pubmed-meshheading:20038637-Cell Differentiation, pubmed-meshheading:20038637-Cell Lineage, pubmed-meshheading:20038637-Immunity, Innate, pubmed-meshheading:20038637-Immunophenotyping, pubmed-meshheading:20038637-Inhibitor of Differentiation Proteins, pubmed-meshheading:20038637-Kruppel-Like Transcription Factors, pubmed-meshheading:20038637-Lymphocyte Count, pubmed-meshheading:20038637-Mice, pubmed-meshheading:20038637-Mice, Inbred C57BL, pubmed-meshheading:20038637-Mice, Knockout, pubmed-meshheading:20038637-Myeloid Progenitor Cells, pubmed-meshheading:20038637-Receptors, Antigen, T-Cell, gamma-delta, pubmed-meshheading:20038637-Signal Transduction, pubmed-meshheading:20038637-T-Lymphocyte Subsets, pubmed-meshheading:20038637-Transcription Factors, pubmed-meshheading:20038637-Zinc Fingers
pubmed:year
2010
pubmed:articleTitle
Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3.
pubmed:affiliation
Immunology Program, Sloan-Kettering Institute, New York, NY, 10065, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural