Linked Life Data

20038281

Source:http://linkedlifedata.com/resource/pubmed/id/20038281

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-12-29
pubmed:abstractText
Effects of exogenous NO donor--dinitrosyl iron complex with reduced glutathione (DNIC-GS) on functional recovery of isolated perfused rat heart subjected to global ischemia and reperfusion have been studied. DNIC-GS administration after ischemia substantially improved contractile and pump function recovery within a concentration range of 34 nM - 5 uM. In case of DNIC-GS administration before ischemia a two-phase influence was found--cardioprotective action for 67 nM and damaging one for 250 nM. Enhanced recovery of cardiac function after preischemic infusion of 67 nM DNIC-GS was associated with augmented preservation of ATP, phosphocreatine, total adenine nucleotide pool and total creatine content in myocardial tissue, and with reduction of lactate dehydrogenase (LDH) release into myocardial effluent compared with these indices in control. In contrast, infusion of 250 nM DNIC-GS resulted in poor recovery of energy metabolism and increased membrane injury than in control. The results suggest that a worse recovery of myocardial energy state and increased sarcolemma permeability in the 250 nM DNIC-GS group were caused by inhibiting oxidation of glucose, the main energy substrate for isolated perfused heart. Molecular mechanisms of protective and injurious action of DNIC-GS on ischemic heart are discussed.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0022-9040
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
[Effects of dinitrosyl iron complex on metabolism and cellular membranes in ischemic rat heart].
pubmed:publicationType
Journal Article, English Abstract