Linked Life Data

20036926

Source:http://linkedlifedata.com/resource/pubmed/id/20036926

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-12-28
pubmed:abstractText
The acute respiratory distress syndrome (ARDS) is associated with a mortality ranging between 40 - 80%. An effective drug therapy, however, is still missing. Many experimental models of ARDS exist enabling a better understanding of the underlying pathophysiology and allowing the establishment of novel therapeutic strategies for the treatment of patients suffering ARDS. Nitric oxide (NO) and reactive nitrogen species (RNS) are increasingly regarded as key substances within the development of ARDS. However, the definite pathomechanism is not completely understood. The purpose of this article is to review the latest results of experimental studies in reference to the role of NO and RNS in the pathogenesis of ARDS. In addition, current large animal models of ARDS are described and future therapeutic approaches are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1945-0524
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-29
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The role of nitric oxide and reactive nitrogen species in experimental ARDS.
pubmed:affiliation
Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-0833, USA. serehber@utmb.edu
pubmed:publicationType
Journal Article, Review