Linked Life Data

20036309

Source:http://linkedlifedata.com/resource/pubmed/id/20036309

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-3-8
pubmed:abstractText
Compared to controls, individuals with generalized anxiety disorder (GAD) often fail to exhibit expected changes in physiological arousal in response to laboratory stressors. Nevertheless, individuals with GAD often report significant subjective arousal. We sought to assess the degree of sympathetic arousal in individuals with GAD and controls and the impact such arousal had on self-reported physiological arousal and response to an emotional challenge. Degree of baseline sympathetic arousal moderated the self-report of physiological arousal in non-comorbid GAD at baseline such that within this group, higher levels of sympathetic arousal predicted reports of heightened physiological arousal compared to controls. Overall, individuals with GAD exhibited no significant changes in arousal in response to the emotional challenge. However, basal sympathetic arousal moderated degree of change such that non-comorbid GAD participants low in baseline sympathetic arousal exhibited changes in arousal similar to controls in response to the stressor. That basal sympathetic arousal moderated both self-reported arousal at baseline and sympathetic response to a stressor suggests important physiological heterogeneity in GAD, wherein only those individuals with heightened tonic sympathetic arousal report accompanying symptoms and display diminished sympathetic reactivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1873-6246
pubmed:author
pubmed:copyrightInfo
Copyright 2009 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-200
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Sympathetic arousal moderates self-reported physiological arousal symptoms at baseline and physiological flexibility in response to a stressor in generalized anxiety disorder.
pubmed:affiliation
The Pennsylvania State University, University Park, PA 16802, United States. ajf226@psu.edu
pubmed:publicationType
Journal Article