Linked Life Data

20035990

Source:http://linkedlifedata.com/resource/pubmed/id/20035990

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-1-29
pubmed:abstractText
Natural materials exhibit anisotropy with variations in soluble factors, cell distribution, and matrix properties. The ability to recreate the heterogeneity of the natural materials is a major challenge for investigating cell-material interactions and for developing biomimetic materials. Here we present a generic fluidic approach using convection and alternating flow to rapidly generate multi-centimeter gradients of biomolecules, polymers, beads and cells and cross-gradients of two species in a microchannel. Accompanying theoretical estimates and simulations of gradient growth provide design criteria over a range of material properties. A poly(ethylene-glycol) hydrogel gradient, a porous collagen gradient and a composite material with a hyaluronic acid/gelatin cross-gradient were generated with continuous variations in material properties and in their ability to regulate cellular response. This simple yet generic fluidic platform should prove useful for creating anisotropic biomimetic materials and high-throughput platforms for investigating cell-microenvironment interactions.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-12091913, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-12818555, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-15020132, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-15603817, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-15791337, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-15987089, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-16259586, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-16408918, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-16477028, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-17000430, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-17713614, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-17720241, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-18369144, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-18651071, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-19231983, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-19255657, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-19458646, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-19680578, http://linkedlifedata.com/resource/pubmed/commentcorrection/20035990-9675204
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1878-5905
pubmed:author
pubmed:copyrightInfo
Copyright 2009 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2686-94
pubmed:dateRevised
2011-7-25
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Convection-driven generation of long-range material gradients.
pubmed:affiliation
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural