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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-2-22
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pubmed:abstractText |
Internal tandem duplication (ITD) mutations of the FLT3 receptor are associated with a high incidence of relapse in acute myeloid leukemia (AML). Expression of the CXCR4 receptor in FLT3-ITD-positive AML is correlated with poor outcome, and inhibition of CXCR4 was shown to sensitize AML blasts toward chemotherapy. The aim of this study was to evaluate the impact of FLT3-ITD on cell proliferation and CXCR4-dependent migration in human hematopoietic progenitor cells and to investigate their response to CXCR4 inhibition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CXCR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/FLT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Heterocyclic Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/JM 3100,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/fms-Like Tyrosine Kinase 3
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1873-2399
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pubmed:author |
pubmed-author:BornhäuserMartinM,
pubmed-author:BrennerSebastianS,
pubmed-author:JacobiAngelaA,
pubmed-author:KochSinaS,
pubmed-author:LehmannRomyR,
pubmed-author:MüllerKatrinK,
pubmed-author:MalechHarry LHL,
pubmed-author:RyserMartinM,
pubmed-author:ThiedeChristianC,
pubmed-author:ThiemeSebastianS,
pubmed-author:UgarteFernandoF
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pubmed:copyrightInfo |
Copyright 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
180-90
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pubmed:meshHeading |
pubmed-meshheading:20035824-Acute Disease,
pubmed-meshheading:20035824-Animals,
pubmed-meshheading:20035824-Bone Marrow Cells,
pubmed-meshheading:20035824-Cell Movement,
pubmed-meshheading:20035824-Cell Proliferation,
pubmed-meshheading:20035824-Cells, Cultured,
pubmed-meshheading:20035824-Coculture Techniques,
pubmed-meshheading:20035824-Flow Cytometry,
pubmed-meshheading:20035824-Hematopoietic Stem Cells,
pubmed-meshheading:20035824-Heterocyclic Compounds,
pubmed-meshheading:20035824-Humans,
pubmed-meshheading:20035824-Leukemia, Experimental,
pubmed-meshheading:20035824-Leukemia, Myeloid,
pubmed-meshheading:20035824-Mice,
pubmed-meshheading:20035824-Mice, Inbred NOD,
pubmed-meshheading:20035824-Mice, SCID,
pubmed-meshheading:20035824-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:20035824-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:20035824-Mutation,
pubmed-meshheading:20035824-Phosphorylation,
pubmed-meshheading:20035824-Receptors, CXCR4,
pubmed-meshheading:20035824-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20035824-STAT3 Transcription Factor,
pubmed-meshheading:20035824-STAT5 Transcription Factor,
pubmed-meshheading:20035824-Transplantation, Heterologous,
pubmed-meshheading:20035824-Tumor Suppressor Proteins,
pubmed-meshheading:20035824-fms-Like Tyrosine Kinase 3
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pubmed:year |
2010
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pubmed:articleTitle |
Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts.
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pubmed:affiliation |
Department of Pediatrics, University Clinic Carl Gustav Carus Dresden, Dresden, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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