Linked Life Data

20035289

Source:http://linkedlifedata.com/resource/pubmed/id/20035289

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pubmed-article:20035289pubmed:abstractTextReduced nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism, is reportedly associated with longevity in the Japanese population. The ND2-237Met genotype may exert resistance to atherogenic diseases, such as myocardial infarction or cerebrovascular disorders. To investigate whether ND2-237 Leu/Met polymorphism is associated with yearly changes in serum lipid levels, we conducted a longitudinal study of 107 healthy Japanese male subjects. Analysis of covariance revealed that the interaction between the ND2-237 Leu/Met genotypes and habitual drinking was significantly associated with yearly changes in serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) levels (p=0.036 and p=0.006, respectively). In multiple regression analysis, daily drinking was significantly and positively associated with yearly changes in serum LDLC levels in men with ND2-237Met (p=0.026). After adjusting for covariates, yearly changes in serum LDLC levels were significantly lower in non-daily drinkers with ND2-237Met than in those with ND2-237Leu (p=0.047). These results suggest that ND2-237Met has a beneficial impact on yearly changes in serum LDLC in non-daily drinkers but not in daily drinkers.lld:pubmed
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pubmed-article:20035289pubmed:articleTitleLongevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of daily alcohol drinking on yearly changes in serum total and LDL cholesterol in Japanese men.lld:pubmed
pubmed-article:20035289pubmed:affiliationDepartment of General Medicine, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.lld:pubmed
pubmed-article:20035289pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20035289pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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