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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0001948,
umls-concept:C0023401,
umls-concept:C0023824,
umls-concept:C0025266,
umls-concept:C0025646,
umls-concept:C0027293,
umls-concept:C0229671,
umls-concept:C0332173,
umls-concept:C0332181,
umls-concept:C0392747,
umls-concept:C0439810,
umls-concept:C0443172,
umls-concept:C1280500,
umls-concept:C1556094,
umls-concept:C1882417
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|
pubmed:issue |
6
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|
pubmed:dateCreated |
2009-12-25
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|
pubmed:abstractText |
Reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism, is reportedly associated with longevity in the Japanese population. The ND2-237Met genotype may exert resistance to atherogenic diseases, such as myocardial infarction or cerebrovascular disorders. To investigate whether ND2-237 Leu/Met polymorphism is associated with yearly changes in serum lipid levels, we conducted a longitudinal study of 107 healthy Japanese male subjects. Analysis of covariance revealed that the interaction between the ND2-237 Leu/Met genotypes and habitual drinking was significantly associated with yearly changes in serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) levels (p=0.036 and p=0.006, respectively). In multiple regression analysis, daily drinking was significantly and positively associated with yearly changes in serum LDLC levels in men with ND2-237Met (p=0.026). After adjusting for covariates, yearly changes in serum LDLC levels were significantly lower in non-daily drinkers with ND2-237Met than in those with ND2-237Leu (p=0.047). These results suggest that ND2-237Met has a beneficial impact on yearly changes in serum LDLC in non-daily drinkers but not in daily drinkers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0386-300X
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pubmed:author |
pubmed-author:HayashiJunichiJ,
pubmed-author:IshikawaMamoruM,
pubmed-author:KaritaKanaeK,
pubmed-author:KitamotoKiyoshiK,
pubmed-author:KokazeAkatsukiA,
pubmed-author:MakitaRyujiR,
pubmed-author:MatsunagaNaomiN,
pubmed-author:OhtsuTadahiroT,
pubmed-author:TakashimaYutakaY,
pubmed-author:TanakaNobukazuN,
pubmed-author:YamamotoMinoruM,
pubmed-author:YoshidaMasaoM
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|
pubmed:issnType |
Print
|
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pubmed:volume |
63
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
331-8
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pubmed:meshHeading |
pubmed-meshheading:20035289-Adult,
pubmed-meshheading:20035289-Alcohol Drinking,
pubmed-meshheading:20035289-Asian Continental Ancestry Group,
pubmed-meshheading:20035289-Body Mass Index,
pubmed-meshheading:20035289-Cholesterol,
pubmed-meshheading:20035289-Cholesterol, LDL,
pubmed-meshheading:20035289-DNA, Mitochondrial,
pubmed-meshheading:20035289-Genotype,
pubmed-meshheading:20035289-Humans,
pubmed-meshheading:20035289-Longevity,
pubmed-meshheading:20035289-Longitudinal Studies,
pubmed-meshheading:20035289-Male,
pubmed-meshheading:20035289-Middle Aged,
pubmed-meshheading:20035289-NADH Dehydrogenase,
pubmed-meshheading:20035289-Polymorphism, Genetic,
pubmed-meshheading:20035289-Regression Analysis
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pubmed:year |
2009
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|
pubmed:articleTitle |
Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of daily alcohol drinking on yearly changes in serum total and LDL cholesterol in Japanese men.
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pubmed:affiliation |
Department of General Medicine, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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